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Anti-Phospho-p120 (Tyr228) Polyclonal Antibody

Anti-Phospho-p120 (Tyr228) Polyclonal Antibody

ArtNr	BOS-P02333
Hersteller	Boster
Menge	100 ul
Kategorie	Neuroscience Targets for Rodent Neurosciences Neural Adhesion Molecules Antibodies Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Catenin delta-1;Cadherin-associated Src substrate;CAS;p120 catenin;p120 (ctn);p120 (cas);CTNND1;KIAA0384;
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Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	108170 MW
Clonality	Polyclonal
Application Details	Western blotting: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications.
Manufacturer - Gene Name	CTNND1
Gene Full Name	Catenin delta-1
Immunogen	Synthesized peptide derived from human p120 around the phosphorylation site of Y228.
Contents	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration	1 mg/ml
Manufacturer - Research Category	Actin, etc., Cytoplasmic, Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction, Signaling Pathways, Stem Cells
Protein Function	Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
Subcellular Localization	Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. Isoforms 4A and 1AB are excluded from the nucleus.
Short Description	Boster Bio Anti-Phospho-p120 (Tyr228) Polyclonal Antibody (Catalog # P02333). Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-Phospho-p120 (Tyr228) Polyclonal Antibody (Catalog # P02333). Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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BOS-P02333-datasheet.pdf

BOS-P02333-safety-datasheet.pdf