curculigoside-a

Description: Curculigoside A, the main saponin found in C. orchioide, is an inducer of angiogenesis through VCAM-1/Egr-3/CREB/VEGF signaling pathway. It exerts significant antioxidant, anti-osteoporosis, antidepressant andneuroprotection effects. Curculigoside possesses significantanti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-kappaB signaling pathway.

References: Curculigosideexerts significant anti arthritic effects in vivo and in vitro viaregulation of the JAK/STAT/NF kappaB signaling pathway. Mol Med Rep. 2019Mar; 19(3):2057-2064.; Yang Y, Ying S, Li T, Zhen J, Chen D, Wang J. A sensitive LC-MS/MS-based bioanalytical method for quantification of salviaflaside and rosmarinic acid in rat plasma and its application in a pharmacokinetic study. Biomed Chromatogr. 2018 Apr 14:e4259. doi: 10.1002/bmc.4259. Epub ahead of print PubMed PMID: 29655233.