GSTM5 Rabbit Polyclonal Antibody

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present| eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha| kappa| mu| omega| pi| sigma| theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds| including carcinogens| therapeutic drugs| environmental toxins and products of oxidative stress| by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual' s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains| as well as in tissue expression patterns| to accommodate an increasing number of foreign compounds.

1 mg/ml

23980