PPIG Polyclonal Antibody

Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0)., The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II., enzyme regulation:Cyclosporin A (CsA)-sensitive., PPIases accelerate the folding of proteins., PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., Belongs to the cyclophilin-type PPIase family., Contains 1 PPIase cyclophilin-type domain., subcellular location:Colocalizes with RNA splicing factors at nuclear speckles., subunit:Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II., tissue specificity:Ubiquitous.,

1 mg/ml

-20°C for 1 year