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PLKK (phospho Ser482 / Ser486 / Ser490) Antibody

PLKK (phospho Ser482 / Ser486 / Ser490) Antibody

ArtNr	PRS-XPS-1022-0.1mL
Hersteller	ProSci
Menge	0.1 mL
Kategorie	Antibodies Western Blot Primary Antibodies
Typ	Antibody Primary
Format	Liquid
Applikationen	WB
Specific against	other
Host	Rabbit
Konjugat/Tag	Unconjugated
Citations	van Vugt, M.A.T.M., van de Weerdt, B.C.M., Vader, G., Janssen, H., Calafat, J., Klompmaker, R., Wolthuis, R.M.F., and Medema, R.H., "Polo-like Kinase-1 Is Required for Bipolar Spindle Formation but Is Dispensable for Anaphase Promoting Complex/Cdc20 Activation and Initiation of Cytokinesis," J. Biol. Chem., 279 (2004) 36,841-36,854. Erikson, E., Haystead, T.A.J., Qian, Y-W., and Maller, J.L., "A Feedback Loop in the Polo-like Kinase Activation Pathway," J. Biol. Chem., 279 (2004) 32,219-32,224. Liu, J., Lewellyn, A.L., Chen, L.G., and Maller, J.L., "The Polo Box Is Required for Multiple Functions of Plx1 in Mitosis," J. Biol. Chem., 279 (2004) 21,367 - 21,373. Kumagai, A., and Dunphy, W. G., "Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts," Science 273 (1996) 1377-1380.
NCBI	plk1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
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Manufacturer - Applications	Applications include Dot Blots (DB) and Western Blots (WB). Suitability for Immunohistochemistry (IHC) has not yet been determined. Xenopus is the only species tested to date. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB.
Shipping Temperature	blue ice or room temperature
Storage Conditions	For long term storage –80°C is recommended, but shorter term storage at –20°C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.
Molecular Weight	120
Manufacturer - Research Area	Signal Transduction , Phospho-Specific
Background	Considerable evidence indicates that a Polo-Like Kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482, 486, 490 in PLKK.
Modifications	Phospho-Specific
Protein Gi #	49036444
Purification	Affinity Purified
Immunogen	PLKK (Ser482/486/490) polyclonal antibody was raised against a synthetic phosphopeptide corresponding to amino acids residues surrounding the Xenopus Phospho-Ser482, 486, 490 PLKK.
Clonality	Polyclonal
NCBI Official Name	polo-like kinase 1
NCBI Organism	Xenopus laevis
Disclaimer	This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

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Menge: 0.1 mL

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