IL-17 Antibody

blue ice or room temperature

Predicted: 17.5kD
Observed: 20 kD (Post-modification: 1 N-linked glycosylation)

IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κ B and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Antibody is affinity chromatography purified via peptide column.

PRS-1208-0.1mg

1 mg/ml

IL-17 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human IL-17A.

The immunogen is located within amino acids 40 - 90 of IL-17.

interleukin 17A

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.