ATG4C Antibody

ArtNr	PRS-7907-0.1mg
Hersteller	ProSci
Menge	0.1 mg
Quantity options	0.02 mg 0.1 mg
Kategorie	Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	Gozuacik D and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004; 23:2891-906. Kisen GO, Tessitore L, Costelli P, et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis 1993; 14:2501-5. Marino G, Uria JA, Puente XS, et al. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. J. Biol. Chem. 2003; 278:3671-8. Korkmaz G, le Sage C, Tekirdag KA, et al. miR-376b controls starvation and TOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy 2012; 8:165-76.
NCBI	ATG4C
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ATG4C Antibody: APG4C, AUTL1, AUTL3, APG4-C, APG4C, Cysteine protease ATG4C, AUT-like 3 cysteine endopeptidase
Lieferbar
Manufacturer - Applications	ATG4C antibody can be used for detection of ATG4C by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Shipping Temperature	blue ice or room temperature
Storage Conditions	ATG4C antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Molecular Weight	Predicted: 50 kDa Observed: 57 kDa
Manufacturer - Research Area	Autophagy
Background	Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1, 2). ATG4C, also known as autophagin-3, is one of four mammalian orthologs of the yeast ATG4 protein; all four are cysteine proteases (3). Recent studies have shown that ATG4C and Beclin-1 are regulated by the microRNA miR-376b; overexpression of miR-376b led to decreased mRNA and protein levels, thereby blocking starvation and TOR inhibition-related autophagy (4).
Protein Gi #	30410846
Purification	ATG4C antibody is affinity chromatography purified via peptide column.
Positive Control 1	PRS-1203-0.1mg
Positive Control 2	PRS-10-101-4um
Concentration	1 mg/ml
Buffer	ATG4C antibody is supplied in PBS containing 0.02% sodium azide.
Immunogen	ATG4C antibody was raised against an 18 amino acid peptide near the carboxy terminus of human ATG4C. The immunogen is located within the last 50 amino acids of ATG4C.
Clonality	Polyclonal
NCBI Official Name	autophagy related 4C, cysteine peptidase
NCBI Organism	homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

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