MLXIP Antibody

ArtNr	PRS-8547-0.1mg
Hersteller	ProSci
Menge	0.1 mg
Quantity options	0.02 mg 0.1 mg
Kategorie	Neuroscience Neuroinflammation Metabolism Glucose Homeostasis Regulation of Appetite Molecular Targets for Neuroscience Antibodies Western Blot ELISA Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	Billin AN, Eilers AL, Coulter KL, et al. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. Mol. Cell Biol. 2000; 20:8845-54. Kaadige MR, Yang J, Wilde BR, et al. MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction. Mol. Cell Biol. 2015; 35:101-10. Carroll PA, Diolaiti D, McFerrin L, et al. Deregulated Myc requires ModoA/Mlx for metabolic reprogramming and tumorigenesis. Cancer Cell 2015; 27:271-85.
NCBI	MLXIP
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	MLXIP Antibody: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E
Lieferbar
Manufacturer - Applications	MLXIP antibody can be used for Western blot at 1 - 2 μg/mL. Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Shipping Temperature	blue ice or room temperature
Storage Conditions	MLXIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	Predicted: 20 kDa Observed: 21 kDa
Manufacturer - Research Area	Homeostasis
Background	MLXIP Antibody: MLXIP is a member of the Myc superfamily of transcription factors and functions as part of a heterodimer with Max-like protein X (MLX) to activate transcription (1). MLXIP contributes to the regulation of glucose homeostasis as the MLXIP/MLX heterodimer activates expression of thioredoxin-interacting protein (TXNIP), a potent inhibitor of cellular glucose uptake and aerobic glycolysis. The mammalian target of rapamycin (mTOR) suppresses the activation of the TXNIP pathway by binding to MLXIP, thereby preventing the MLXIP/MLX heterodimer formation (2). MLXIP interaction with Myc may also be involved in metabolic reprogramming and tumorigenesis (3).
Protein Gi #	111955326
Purification	MLXIP Antibody is affinity chromatography purified via peptide column.
Positive Control 1	PRS-1219-0.1mg
Concentration	1 mg/ml
Buffer	MLXIP Antibody is supplied in PBS containing 0.02% sodium azide.
Homology	Predicted species reactivity based on immunogen sequence: Mouse: (95%)
Immunogen	MLXIP antibody was raised against a peptide corresponding to 19 amino acids near the amino terminus of human MLXIP.
Clonality	Polyclonal
NCBI Official Name	MLX interacting protein
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

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