Recombinant Human 2B4/CD244 Protein (His Tag)(Active)

This product is provided as lyophilized powder which is shipped with ice packs.

45-50 kDa

The CD244 antigen; also known as 2B4; is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production; which is expressed on all NK cells; a subpopulation of T cells; monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor; human 2B4 can effectively activate and enhance NK cell– mediated cytotoxicity; induce secretion of IFN-γ and matrix metalloproteinases (MMPs); as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2; CD48; CD58; CD84; Ly-9; and SLAM; 2B4 (CD244) is expressed on all human NK cells; a subpopulation of T cells; basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity; induces secretion of IFN-gamma and matrix metalloproteinases; and NK cell invasiveness.Immune CheckpointImmune Checkpoint Detection: Antibodies      Immune Checkpoint Detection: ELISA Antibodies      Immune Checkpoint Detection: IP Antibodies      Immune Checkpoint Detection: FCM AntibodiesImmune Checkpoint ProteinsImmune Checkpoint Targets      Co-inhibitory Immune Checkpoint Targets Immunotherapy      Cancer Immunotherapy      Targeted Therapy

Please refer to the printed manual for detailed information.

Measured by its binding ability in a functional ELISA. Immobilized human 2B4 at 2 ug/ml (100 ul/well) can bind human CD48. The EC50 of human CD48 is 0.39 ug/ml.