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MAP2K2 Monoclonal Antibody

MAP2K2 Monoclonal Antibody

ArtNr	E-AB-22163-20
Hersteller	Elabscience
Menge	20 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Kategorie	Oncology Neuroscience Neural Signaling Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Western Blot Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB
Clon	7D11
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Cardiofaciocutaneous syndrome, CFC syndrome, CFC4, Dual specificity mitogen activated protein kinase kinase 2, Dual specificity mitogen-activated protein kinase kinase 2, ERK activator kinase 2, FLJ26075, MAP kinase kinase 2, map2k2, MAPK / ERK kinase 2, MAPK/ERK kinase 2, MAPKK 2, MAPKK2, MEK 2, MEK2, Microtubule associated protein kinase kinase 2, Mitogen activated protein kinase kinase 2, Mitogen activated protein kinase kinase 2 p45, MKK 2, MKK2, MP2K2, OTTHUMP00000165826, OTTHUMP00000165827, PRKMK 2, PRKMK2
Similar products	MAPKK2, MEK2, Dual specificity mitogen-activated protein kinase kinase 2, ERK activator kinase 2, MAPK/ERK kinase 2, MKK2, PRKMK2, map2k2, FLJ26075, MAP kinase kinase 2, MP2K2, Cardiofaciocutaneous syndrome, CFC syndrome, MAPK / ERK kinase 2, MAPKK 2, MEK 2, Mitogen activated protein kinase kinase 2, Mitogen activated protein kinase kinase 2 p45, MKK 2, OTTHUMP00000165826, OTTHUMP00000165827, PRKMK 2, CFC4, Dual specificity mitogen activated protein kinase kinase 2, Microtubule associated protein kinase kinase 2
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Category	Monoclonal Antibody
Shipping Temperature	Biological Ice Packs
Storage Conditions	-20°C for 12 months
Observed Molecular Weight	45kDa
Research Areas	Cancer, Signal Transduction
Background	The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Concentration	1 mg/mL
Buffer	PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH 7.4
Purification Method	Protein A purification
Recommended Dilution	WB 1:500-1:2000, IHC 1:100-1:300, IP 1:200-1:500, ELISA 1:10000
Clonality	Monoclonal
Immunogen	Synthesized peptide derived from human MEK-2 around the non-phosphorylation site of T394.

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