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SARS-CoV-2 (COVID-19) S1 protein (N501Y), His Tag Europäischer Partner

ArtNr S1N-C52Hg-1mg
Hersteller ACROBiosystems
Menge 250 ug x 4
Quantity options 100 ug 250 ug x 4
Kategorie
Typ Proteins Recombinant
Format Solid
Specific against SARS-CoV-2
Host HEK293
Konjugat/Tag Unconjugated, HIS
Purity 90%
Citations (1) Wan Y, et al. J Virol. 2020. pii: JVI.00127-20. (2) Benvenuto D, et al. J Med Virol. 2020. (3) Chang CY, et al. AMB Express. 2020. 10(1):20.
NCBI QHD43416.1 (N501Y)
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Category
Protein / Viral Proteins
Manufacturer - Conjugate / Tag
C-10xHis, Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
76.9 kDa
Manufacturer - Format
Powder
Description
SARS-CoV-2 S1 protein (N501Y), His Tag (S1N-C52Hg) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Arg 685 (Accession # QHD43416.1 (N501Y)). N501Y mutaion was identified in multiple SARS-CoV-2 Variants of Concerns (VOCs), i.e. the Alpha variant (Pango lineage: B.1.1.7; other names: 20I/501Y.V1 or VOC 202012/01), the Beta variant (Pango lineage: B.1.351; other names: 20H/501Y.V2), the Gamma variant (Pango lineage: P.1; other names: 20J/501Y.V3).
Background
It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Molecule
Spike S1
Exp Region
Val 16 - Arg 685
Characteristics
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 76.9 kDa. The protein migrates as 110-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
1.0 EU per μg
Buffer
PBS, pH 7.4
Stability
● -20°C to -70°C for 12 months in lyophilized state;
● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 250 ug x 4
Lieferbar: In stock
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