bms-346567

InvivoChem Cat #:V3516CAS #:953807-31-3Purity >=98%

Description: BMS-346567, an analog of Sparsentan, is a novel, potent and selective dual angiotensin II and endothelin A receptor antagonist. BMS-346567 demonstrated superiority over irbesartan (an AT(1) receptor antagonist) in the normal SHR model of hypertension in a dose-dependent manner, demonstrating the synergy of AT(1) and ET(A) receptor blockade in a single molecule. Sparsentan (formerly known as RE-021; BMS-346567; PS433540; DARA-a) is a novel, highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively. In rats, DARA 7 reduced blood pressure elevations caused by intravenous infusion of Ang II or big ET-1 to a greater extent and with longer duration than DARA 3 or AT(1) or ET(A) receptor antagonists alone. Compound 7 clearly demonstrated superiority over irbesartan (an AT(1) receptor antagonist) in the normal SHR model of hypertension in a dose-dependent manner, demonstrating the synergy of AT(1) and ET(A) receptor blockade in a single molecule.

References: J Med Chem. 2005 Jan 13; 48(1):171-9.

-20C for 3 years in powder form

Synonym: BMS346567; BMS 346567; BMS-346567.
Chemical Name: 4'-((2-butyl-4-oxo-1, 3-diazaspiro[4.5]dec-1-en-3-yl)methyl)-N-(4, 5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-[1, 1'-biphenyl]-2-sulfonamide
InChi Key: CWMQUSPFWVHUGW-UHFFFAOYSA-N
InChi Code: InChI=1S/C33H42N4O5S/c1-5-7-15-30-34-33(18-11-8-12-19-33)32(38)37(30)21-25-16-17-27(26(20-25)22-41-6-2)28-13-9-10-14-29(28)43(39, 40)36-31-23(3)24(4)42-35-31/h9-10, 13-14, 16-17, 20H, 5-8, 11-12, 15, 18-19, 21-22H2, 1-4H3, (H, 35, 36)
SMILES Code: CCCCC1=NC2(C(N1CC(C=C3COCC)=CC=C3C4=CC=CC=C4S(NC5=NOC(C)=C5C)(=O)=O)=O)CCCCC2