TBX21 Antibody (N-term)

NP_037483.1

This gene is a member of a phylogenetically conserved
family of genes that share a common DNA-binding domain, the T-box.
T-box genes encode transcription factors involved in the regulation
of developmental processes. This gene is the human ortholog of
mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is
a Th1 cell-specific transcription factor that controls the
expression of the hallmark Th1 cytokine, interferon-gamma (IFNG).
Expression of the human ortholog also correlates with IFNG
expression in Th1 and natural killer cells, suggesting a role for
this gene in initiating Th1 lineage development from naive Th
precursor cells.

30009

H

22-50

This TBX21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human TBX21.