Vergleich

Metabotropic Glutamate Receptor 7 (GPRC1G) Antibody (C-term)

ArtNr ABC-AP1640A-ev-80ul
Hersteller Abcepta
Menge 80 ul
Kategorie
Typ Antibody Polyclonal
Applikationen Western Blot, Immunohistochemistry
Specific against other
Host Rabbit
Isotype Ig
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Metabotropic glutamate receptor 7, mGluR7, GRM7, GPRC1G, MGLUR7
Lieferbar
Primary Accession
Q14831
Other Accession
P35400; Q68ED2; NP_870989
Antigen Type
Synthetic Peptide
Bio Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.
Bio References
Schulz, H.L., et al., Neurosci. Lett. 326(1):37-40 (2002).
Flor, P.J., et al., Neuropharmacology 36(2):153-159 (1997).
Makoff, A., et al., Brain Res. Mol. Brain Res. 40(1):165-170 (1996).
Scherer, S.W., et al., Genomics 31(2):230-233 (1996).
Okamoto, N., et al., J. Biol. Chem. 269(2):1231-1236 (1994).
Gene ID
2917
Gene Name
GRM7
Reactivity
H
Predicted
M, Rat
Calculated MW
102251
Antigen Region
857-887
Antigen Source
HUMAN
Target/Specificity
This Metabotropic Glutamate Receptor 7 (GPRC1G) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 857-887 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 7 (GPRC1G).
NCBI Accession
NP_000835.1; NP_870989.1

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