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MBD3 Antibody (N-term)

MBD3 Antibody (N-term)

ArtNr	ABC-AP13755a-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MBD3, Methyl-CpG-binding domain protein 3, Methyl-CpG-binding protein MBD3
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Primary Accession	O95983
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.
Bio References	Bachmann, N., et al. Eur J Med Genet 53(1):23-24(2010) Noh, E.J., et al. Biochem. Biophys. Res. Commun. 378(3):332-337(2009) Morey, L., et al. Mol. Cell. Biol. 28(19):5912-5923(2008) Brown, S.E., et al. Gene 420(2):99-106(2008) Spensberger, D., et al. Biochemistry 47(24):6418-6426(2008)
Clonality	Polyclonal
Clone/Animal Names	RB33769
Gene ID	53615
Gene Name	MBD3
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	MBD3 Antibody (N-term) (Cat. #AP13755a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MBD3 antibody detected the MBD3 protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Other Accession	Q9Z2D8; NP_003917.1
Predicted	M
Isotype	Rabbit Ig
Calculated MW	32844
Antigen Region	1-30
Antigen Source	HUMAN
Target/Specificity	This MBD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MBD3.
NCBI Accession	NP_001268382.1; NP_001268383.1

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Menge: 80 ul

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