HMGCR Antibody (Center)

Synthetic Peptide

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.

Polyclonal

3156

Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of HMGCR antibody (Center) (Cat. #AP6577c) in Jurkat cell line lysates (35ug/lane). HMGCR (arrow) was detected using the purified Pab.

1:1000

IHC-P

Rabbit Ig

380-410

This HMGCR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380~410 amino acids from the Center region of human HMGCR.