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FKBP5 Antibody (monoclonal) (M02)

FKBP5 Antibody (monoclonal) (M02)

ArtNr	ABC-AT2058a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, IF, ELISA
Clon	3D1-1B10
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	FKBP5, AIG6, FKBP51, FKBP54, Rotamase, 54 kDa progesterone receptor-associated immunophilin, FF1 antigen, HSP90-binding immunophilin, p54, FKBP-5, FKBP-51, Peptidyl-prolyl cis-trans isomerase FKBP5, PPIase FKBP5, 51 kDa FK506-binding protein, 51 kDa FKBP, Androgen-regulated protein 6, FK506-binding protein 5
Lieferbar
Primary Accession	Q13451
Antigen Type	Recombinant Protein
Application	WB, IF, E
Bio Background	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
Bio References	Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals. Tatro ET, et al. J Neurovirol, 2010 Aug 20. PMID 20726698.Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders. Zou YF, et al. Neurosci Lett, 2010 Oct 22. PMID 20709156.FKBP5 and resistant attachment predict cortisol reactivity in infants: Gene-environment interaction. Luijk MP, et al. Psychoneuroendocrinology, 2010 May 21. PMID 20547006.Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. Saus E, et al. J Psychiatr Res, 2010 Apr 14. PMID 20398908.Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder. Xie P, et al. Neuropsychopharmacology, 2010 Jul. PMID 20393453.
Clonality	Monoclonal
Gene ID	2289
Gene Name	FKBP5
Subtitle	Mouse monoclonal antibody raised against a full length recombinant FKBP5.
Reactivity	H
Legend image 1	Immunofluorescence of monoclonal antibody to FKBP5 on HeLa cell . [antibody concentration 10 ug/ml]
Type image 1	IF
Legend image 2	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (76.01 KDa) .
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	Detection limit for recombinant GST tagged FKBP5 is approximately 0.03ng/ml as a capture antibody.
Type image 3	E
Other Accession	BC042605
Isotype	IgG2b Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	FKBP5 (AAH42605, 1 a.a. ~ 457 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001139247.1; NP_001139248.1; NP_001139249.1; NP_004108.1
	Clone: 3D1-1B10
Org Accession	AAH42605
Gene Description	FK506 binding protein 5
Gene Summary	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq

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Menge: 100 ug

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