Anti-Human NALP1

ArtNr	LEIN-N157-0.1mg
Hersteller	Leinco Technologies
Menge	0.1 mg
Quantity options	0.1 mg 20 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Tschopp, J. et al. (2003) Nat. Rev. Mol. Cell Biol. 4:95 2. Chu. ZL. et al. (2001) J. Biol. Chem. 276:9239 3. Hlaing, T. et al. (2001) J. Biol. Chem. 276:9230 4. Sanz, C. et al. (2004) Biochem. J. 384:281
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	NALP1
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	NALP1 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli.1 It contains a caspase recruitment domain (CARD) in addition to a NACHT domain and leucine rich repeat (LRR). This protein interacts strongly with caspase 2 and weakly with caspase 9, as well as with Apaf-1.2 Transient overexpression of this gene in cultured cells was sufficient to induce apoptosis.3 NALP1 mRNA and protein expression levels in myeloid leukemia cells are increased following CREB (cAMP-response element binding protein) activation, suggesting that NALP1 may contribute to modulate the response of these cells to pro-inflammatory stimuli.4 Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for NALP1.3
Background	NALP1 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli.¹ It contains a caspase recruitment domain (CARD) in addition to a NACHT domain and leucine rich repeat (LRR). This protein interacts strongly with caspase 2 and weakly with caspase 9, as well as with Apaf-1.² Transient overexpression of this gene in cultured cells was sufficient to induce apoptosis.³ NALP1 mRNA and protein expression levels in myeloid leukemia cells are increased following CREB (cAMP-response element binding protein) activation, suggesting that NALP1 may contribute to modulate the response of these cells to pro-inflammatory stimuli.⁴ Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for NALP1.³
PubMed	NALP1
Manufacturer - Specificity	Rabbit Anti-Human NALP1 recognizes Human NALP1. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2831415
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:N170
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

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LEIN-N157-0.1mg-safety-datasheet.pdf