Bocidelpar

ArtNr	HY-134377-1ea
Hersteller	MedChem Express
CAS-Nr.	2095128-20-2
Menge	1 ea
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Molecules
Specific against	other
Purity	98.08
Citations	[1]Ito M, et al. Single- and multiple-dose safety, tolerability, pharmacokinetic, and pharmacodynamic profiles of ASP0367, or bocidelpar sulfate, a novel modulator of peroxisome proliferator-activated receptor delta in healthy adults: Results from a phase 1 study. Muscle Nerve. 2022 Jan;65(1):110-120.\|[2]Diniz Gulden, et al. A Quick Glance at the Therapeutic Approaches for Neuromuscular Disorders. Clues for Differential Diagnosis of Neuromuscular Disorders. Cham: Springer International Publishing, 2023. 329-344.
Smiles	O=C(O)C[C@H](C)CCCOC1=CC=CC=C1CN2C(C)=CN=C2C3=CC=C(C(F)(F)F)C=C3
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	ASP0367,MA-0211
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	PPAR
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	460.49
Product Description	Bocidelpar (ASP0367; MA-0211) is a selective, orally active PPARδ modulator. Bocidelpar activates the PPARδ downstream signaling pathway, upregulates the expression of target genes such as ABCA1 and ACAA2. Bocidelpar then promotes fatty acid oxidation (FAO) and mitochondrial biogenesis, and improves mitochondrial dysfunction. Bocidelpar can improve mitochondrial biogenesis and function in muscle cells. Bocidelpar is mainly used in the study of mitochondrial dysfunction diseases such as primary mitochondrial myopathy (PMM) and Duchenne muscular dystrophy (DMD)[1][2].
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO: 250 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Clinical information	Phase 2

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HY-134377-1ea-safety-datasheet.pdf