Serine/threonine-Protein Kinase TBK1 (Tbk1) Antibody

Serine/threonine-Protein Kinase TBK1 (Tbk1)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of a TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response.

PBS containing 0.09% sodium azide.

This product is for research use only.

TBK1_MOUSE