Recombinant human CD16b/FCGR3B protein

Recombinant Protein

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

FCGR3B, also known as low affinity immunoglobulin gamma Fc region receptor III-B isoform 2, is a member of Ig super family. It encodes a glycosylphosphatidylinositol (GPI) -anchored protein that is expressed constitutively by neutrophils and after gamma-interferon stimulation by eosinophils. This protein binds to complex or aggregated IgG and monomeric IgG. Unlike III-A, it cannot mediate antibody-dependent cytotoxicity and phagocytosis. It can be a trap of immune complexes in peripheral blood circulation that does not activate neutrophils. Recombinant human FCGR3B, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Immunology

< 1 EU per 1ug of protein (determined by LAL method)

Human