MAPT 412a.a. Microtubule-Associated Protein Tau 412 a.a. Human Recombinant Protein

Solution

The MAPT solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) and 20% glycerol.

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.