DDR1 Antibody

ArtNr	ABC-AM8458b
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Mouse
Isotype	IgG2b kappa
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	TRK, Epithelial discoidin domain-containing receptor 1, CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10, Protein-tyrosine kinase 3A, Epithelial discoidin domain receptor 1, MCK-10, Protein-tyrosine kinase RTK-6
Lieferbar
Primary Accession	Q08345
Application	WB, IHC-P
Bio Background	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Bio References	di Marco E., et al.J. Biol. Chem. 268:24290-24295(1993). Johnson J.D., et al.Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681(1993). Laval S., et al.Cell Growth Differ. 5:1173-1183(1994). Perez J.L., et al.Oncogene 9:211-219(1994). Sakuma S., et al.FEBS Lett. 398:165-169(1996).
Clonality	monoclonal
Clone/Animal Names	1464CT339.1.54
Gene ID	780
Gene Name	DDR1
Subtitle	Purified Mouse Monoclonal Antibody (Mab)
Reactivity	H
Legend image 1	Western blot analysis of lysate from MCF-7 cell line, using DDR1 Antibody(Cat. #AM8458b). AM8458b was diluted at 1:1000. A goat anti-mouse IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20μg.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	AM8458b staining DDR1 in human brain sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
Type image 2	IHC-P
Dilution image 2	1:25
Isotype	IgG2b, k
Calculated MW	101128
Antigen Source	HUMAN
Target/Specificity	This DDR1 antibody is generated from a mouse immunized with a recombinant protein.

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ABC-AM8458b-datasheet.pdf

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Menge: 400 ul

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Lieferung vsl. bis 02.10.2025

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