SMURF2 Antibody

ArtNr	CSB-PA872532EA01HU-50ug
Hersteller	Cusabio
Menge	50 ug
Quantity options	100 ug 20 ug 50 ug
Kategorie	Neuroscience Aging & Neurological Disorders Antibodies Cell Biology Cell Status Immunohistochemistry ELISA Autophagy Senescence Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	E3 ubiquitin-protein ligase SMURF2 antibody; EC 6.3.2. antibody; hSMURF2 antibody; MGC138150 antibody; Smad specific E3 ubiquitin ligase 2 antibody; SMAD specific E3 ubiquitin protein ligase 2 antibody; SMAD ubiquitination regulatory factor 2 antibody; SMAD-specific E3 ubiquitin-protein ligase 2 antibody; SMUF2_HUMAN antibody; Smurf2 antibody; Ubiquitin protein ligase SMURF2 antibody
Similar products	SMURF2, E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Targets	SMURF2
Storage Conditions	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Manufacturer - Alias	E3 ubiquitin-protein ligase SMURF2 antibody; EC 6.3.2. antibody; hSMURF2 antibody; MGC138150 antibody; Smad specific E3 ubiquitin ligase 2 antibody; SMAD specific E3 ubiquitin protein ligase 2 antibody; SMAD ubiquitination regulatory factor 2 antibody; SMAD-specific E3 ubiquitin-protein ligase 2 antibody; SMUF2_HUMAN antibody; Smurf2 antibody; Ubiquitin protein ligase SMURF2 antibody
Immunogen Species	Human
Immunogen	Recombinant Human E3 ubiquitin-protein ligase SMURF2 protein (1-748AA)
Dilution	ELISA:1:2000-1:10000 IHC:1:20-1:200
Background	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method	>95%, Protein G purified
General Research Areas	Epigenetics and Nuclear Signaling
Initial Research Areas	Epigenetics and Nuclear Signaling
Antigen Species	Human
Antigen	Recombinant Human E3 ubiquitin-protein ligase SMURF2 protein (1-748AA)
Clonality	Polyclonal

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Menge: 50 ug

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Lieferung vsl. bis 28.08.2025

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