|
Hersteller |
Cell Sciences |
|
Kategorie |
|
|
Typ |
Antibody |
|
Specific against |
Human |
|
Isotype |
IgG |
|
Applikationen |
WB, IF |
|
Menge |
100 ug |
|
Host |
Rabbit |
|
ArtNr |
CS-CMC433 |
|
eClass 6.1 |
32160702 |
|
eClass 9.0 |
32160702 |
|
Lieferbar |
 |
| Applications |
Western Blot Immunoprecipitation Immunofluorescence |
| Description |
Rabbit Anti-Human Caspase 1 Affinity Purified polyclonal antibody. Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase 1 is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1a and IL18 into active cytokines. Like other caspases, Caspase 1 itself is synthesized as a pro-enzyme that is cleaved during activation into large (20 kDa) and small (10 kDa) subunits. The cellular role of caspase 1 appears limited to cytokine activation as they do not have obvious roles in apoptosis. |
| Formulation |
Liquid in PBS, pH 7.2 + 30% glycerol + 0.5% BSA + 0.01% thimerosal. Precaution: Thimerosal is a poisonous and hazardous substance which should be handled by trained staff only. |
| Specificity |
Recognizes 45 kDa pro-caspase 1 and the 20 kDa cleaved product. |
| Immunogen |
Synthetic peptide surrounding amino acid 132 of human caspase 1 |
| Purification |
Biospecific affinity chromatography |
| Storage and Stability |
Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles. |
| Cross-Reactivity |
Reacts with human, mouse, and rat. |
