Antibodies

Rabbit Anti-Human APAF1 Affinity Purified pAb

Hersteller Cell Sciences
Kategorie
Typ Antibody
Specific against Human
Isotype IgG
Applikationen WB
Menge 100 ug
Host Rabbit
ArtNr CS-CPA103
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Applications
Western Blot
Description
Rabbit Anti-Human APAF1 Affinity Purified polyclonal antibody. During apoptosis, APAF1 binds to cytochrome c (APAF2), a reaction that requires dATP, and this leads to the formation of a large multimeric complex. The complex recruits pro-caspase 9, and activates caspase 9 (APAF3). Activated caspase 9 in turn cleaves and activates caspase 3, one of the proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. APAF1 is ubiquitously expressed in human tissues.
Formulation
Liquid in PBS, pH 7.2 + 30% glycerol + 0.05% BSA + 0.01% thimerosal. Precaution: Thimerosal is a poisonous and hazardous substance which should be handled by trained staff only.
Specificity
Detects a 130 kDa protein corresponding to the apparent molecular weight of APAF1 on SDS-PAGE immunoblots.
Immunogen
Synthetic peptide surrounding amino acid 1161 of human APAF1
Purification
Biospecific affinity chromatography
Storage and Stability
Store at -20C or in working aliquots at -80C for long term storage. Avoid repeated freeze-thaw cycles.
Cross-Reactivity
Reacts with human, mouse, rat, cow, rabbit, hamster, guinea pig, and monkey.

Arbeitsanleitung

CS-CPA103.pdf

Menge: 100 ug
Lieferbar: In stock
Listenpreis: 610,67 €
Preis: 610,67 €
lieferbar

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Arne Pelz

sales@hoelzel.de