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Recombinant Human NAP-2/CXCL7

Recombinant Human NAP-2/CXCL7

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Hersteller	Cell Sciences
Kategorie	Proteins Neuroscience Neuroinflammation Metabolism Diabetes
Typ	Proteins
Specific against	Human
Menge	1.0 mg
Host	E.coli
ArtNr	CS-CRN600C
eClass 6.1	34160400
eClass 9.0	42020190
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Description	Neutrophil Activating Peptide 2 (NAP-2) is proteolytically processed carboxyl-terminal fragments of platelet basic protein (PBP) which is found in the alpha-granules of human platelets. NAP-2 is a member of the CXC chemokines. Similar to other ELR domain containing CXC chemokines such as IL-8 and the GRO proteins, NAP-2 has been shown to bind CXCR-2 and to chemoattract and activate neutrophils. Although CTAP-III, beta-TG and PBP represent amino-terminal extended variants of NAP-2 and possess the same CXC chemokine domains, these proteins do not exhibit NAP-2 activity. Recently, it has been shown that the additional amino-terminal residues of CTAP-III masks the critical ELR receptor binding domain that is exposed on NAP-2 and may account for lack of NAP-2 activity.
Formulation	Lyophilized from a sterile filtered solution in 20 mM PB, pH 7.4 + 50 mM NaCl
Reconstitution	Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.
Storage and Stability	Stable at 2-4C, but best kept desiccated -20C. Upon reconstitution, stable for up to 1 week at 2-4C. For longer term, store in working aliquots below -20C. Avoid repeated freeze/thaw cycles.
GeneID	5473
Source	E. coli
Molecular Weight	7.6 kDa
Purity	>97% by HPLC and SDS-PAGE
Endotoxin Level	Less than 1 EU/ug of rHuNAP-2/CXCL7 as determined by LAL method.
Biological Activity	Determined by the ability of NAP2 to chemoattract human neutrophils using a concentration of 1-10 ng/ml.
AA Sequence	AELRCMCIKT TSGIHPKNIQ SLEVIGKGTH CNQVEVIATL KDGRKICLDP DAPRIKKIVQ KKLAGDESAD

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