Similar products |
NAP-2, TC1, PBP, member 7, beta-1, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, SCYB7, TC2, TGB, TGB1, THBGB, THBGB1, CXC chemokine ligand 7, beta-thromboglobulin, connective tissue-activating peptide III, leukocyte-derived growth factor, low-affinity platelet factor IV, macrophage-derived growth factor, neutrophil-activating peptide 2, neutrophil-activating peptide-2, platelet basic protein, pro-platelet basic protein, small inducible cytokine B7, small inducible cytokine subfamily B, thrombocidin 1, thrombocidin 2, thromboglobulin |
Storage Conditions |
Stable at 2-4C, but best kept desiccated -20C. Upon reconstitution, stable for up to 1 week at 2-4C. For longer term, store in working aliquots below -20C. Avoid repeated freeze/thaw cycles. |
Description |
Neutrophil Activating Peptide 2 (NAP-2) is proteolytically processed carboxyl-terminal fragments of platelet basic protein (PBP) which is found in the alpha-granules of human platelets. NAP-2 is a member of the CXC chemokines. Similar to other ELR domain containing CXC chemokines such as IL-8 and the GRO proteins, NAP-2 has been shown to bind CXCR-2 and to chemoattract and activate neutrophils. Although CTAP-III, beta-TG and PBP represent amino-terminal extended variants of NAP-2 and possess the same CXC chemokine domains, these proteins do not exhibit NAP-2 activity. Recently, it has been shown that the additional amino-terminal residues of CTAP-III masks the critical ELR receptor binding domain that is exposed on NAP-2 and may account for lack of NAP-2 activity. |