Recombinant Human Thioredoxin

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Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 50 ug
Host E.coli
ArtNr CS-CRT139B
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
Thioredoxins are small disulphide-containing redox proteins (within the conserved Cys-Gly-Pro-Cys active site) that have been found in all the kingdoms of living organisms. Thioredoxin contains a single disulfide active site and serves as a general protein disulphide oxidoreductase. Thioredoxins are involved in the first unique step in DNA synthesis. It interacts with a broad range of proteins by a redox mechanism based on reversible oxidation of two cysteine thiol groups to a disulphide, accompanied by the transfer of two electrons and two protons. The net result is the covalent interconversion of a disulphide and a dithiol. It has been suggested that thioredoxin may catalyze the formation of correct disulfides during protein folding because of its ability to act as an efficient oxidoreductant. Trx also provides control over a number of transcription factors affecting cell proliferation and death through a mechanism referred to as redox regulation. Thioredoxin Human Recombinant produced in, E. coli, is a single, non-glycosylated, polypeptide chain containing 105 amino acids.
Formulation
Thioredoxin solution containing 20 mM phosphate buffer pH 7.4.
Storage and Stability
Thyrodoxin human although stable at 4C for 1 week, should be stored desiccated below -18C. Please prevent freeze thaw cycles.
GeneID
7295
Source
E. coli
Molecular Weight
11.7 kDa
Purity
Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE
Protein Accession No
P10599
Biological Activity
Specific activity is 7-10 A650/min/mg, obtained by measuring the increase of insulin precipitation in absorbance at 650 nm resulting from the reduction of insulin. Please refer to our activity assay protocol.
AA Sequence
MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFFKKGQKVGEFS GANKEKLEAT INELV.

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Menge: 50 ug
Lieferbar: In stock
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