Recombinant Human TFF3

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Hersteller Cell Sciences
Kategorie
Typ Proteins
Specific against Human
Menge 20 ug
Host E.coli
ArtNr CS-CRT189B
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Description
Members of the Trefoil family are characterized by having at least one copy of the Trefoil motif, a 40-amino acid domain that contains three conserved disulfides. Trefoil Factors (TFF1, TFF2 and TFF3) are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not well-defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. Trefoil Factor 1 (TFF1) is essential for normal differentiation of the antral and pyloric gastric mucosa and functions as a gastric-specific tumor suppressor gene. Trefoil Factor 2 (TFF2) inhibits gastric acid motility and secretion. TFF2 stabilizes glycoproteins in the mucus gel through interactions with carbohydrate side chains. Trefoil Factor 3 (TFF3) is expressed in goblet cells of the intestines and colon. TFF3 induces ciliogenesis and promotes airway epithelial ciliated cell differentiation, relatively through an Epidermal Growth Factor Receptor (EGFR)-dependent pathway. TFF3 overexpression is crucial for progression in Mouse and Human hepatocellular carcinogenesis. TFF-3 is normally expressed in hepatocellular carcinoma and its expression associates with tumor grade. The three Trefoil Factor genes are found in a cluster on chromosome 21. Recombinant Human TFF3 is a single, non-glycosylated polypeptide chain containing 69 amino acids (22-80 aa) which includes a 10 amino acid His Tag fused at N-terminus.
Formulation
Lyophilized filtered solution containing 20 mM Tris pH 7.5 + 150 mM NaCl.
Reconstitution
Centrifuge vial prior to opening . Add deionized water to a working concentration approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. PRODUCT IS NOT STERILE!, Please filter the product by appropriate sterile filter before using it in the cell culture.
Storage and Stability
Stable at room temperature for 3 weeks, best stored desiccated below -20C. After reconstitution, store at 4C no more than 1 week or -20C for longer term. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.
GeneID
7033
Source
E. coli
Molecular Weight
7.82 kDa
Purity
>95% by SDS-PAGE
AA Sequence
MK HHHHHH AS EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF

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Menge: 20 ug
Lieferbar: In stock
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