Recombinant Rat VEGFC His

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Hersteller Cell Sciences
Typ Proteins
Specific against Rat
Menge 2 ug
Host Insect
ArtNr CS-CRV006A
eClass 6.1 34160400
eClass 9.0 42020190
Vascular Endothelial Growth Factor C (VEGF-C) is A VEGF growth factor family member that is most closely related to VEGF-D. Like VEGF-D, VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults, VEGF-C is highly expressed in heart, placenta, ovary and small intestine. Recombinant rat VEGF-C, lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain, forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT -4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells, it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant rat VEGF-C is also a mitogen for vascular endothelial cells, it is much less potent than VEGF-A. Recombinant Rat VEGF-C contains 129 amino acids fused to a 6x His tag at the C-terminal end. As a result of glycosylation, VEGF-C migrates as an 18-24 kDa protein in SDS-PAGE under reducing conditions.
Each mg of VEGF-C Rat contains 50 mg BSA and PBS as buffer.
Reconstitute the lyophilized Vascular Endothelial Growth Factor C in sterile distilled water at not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Storage and Stability
Lyophilized Vascular Endothelial Growth Factor-C should be stored desiccated below -20C. Upon reconstitution, VEGF-C may be stored at 2-4C for 1 week. For future use, store below -20C. Avoid repeated freeze-thaw cycles.
Sf9 Insect Cells.
Biological Activity
Measured by its ability to stimulate phosphorylation of the VEGFR-3/FLT-4 receptor in pig aortic endothelial cells. The ED50 for this effect is typically 200-300 ng/ml corresponding to a Specific Activity of 3, 334-5, 000 IU/mg.

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Menge: 2 ug
Lieferbar: In stock


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