KDU691

1513879-19-0

C22H18ClN5O2

DMSO : 150 mg/mL (357.26 mM; Need ultrasonic and warming)

PI3K/Akt/mTOR

KDU691 is a PI4K inhibitor. IC50 & Target: PI4K^[1] In Vivo: During the 5 days of dosing, no major weight changes are observed in the animals that receive KDU691 as prophylactic treatment (group 691-proph). From the fourth day of dosing, the animals that are treated with KDU691 show a transient yellow skin color. The KDU691 radical-cure group (group 691-RC) becomes blood-stage positive again at 31.8+/-0.5 days p.i. (range, 31 to 32 days). Clinical chemistry analysis of the group 691-RC monkeys reveals that bilirubin levels accumulate during the 5-day radical-cure treatment with KDU691^[1].