D-Lin-MC3-DMA

1224606-06-7

C43H79NO2

DMSO : >= 43.33 mg/mL (67.48 mM); Ethanol : 16.67 mg/mL (25.96 mM; Need ultrasonic)

Others

D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle. In Vivo: Lipid nanoparticles (LNPs) containing distearoylphosphatidlycholine (DSPC), and ionizableamino-lipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo. LNP-siRNA systems optimize to achieve maximum gene silencing potency in hepatocytesfollowing IV administration in mice contain DLin-MC3-DMA (MC3), DSPC, cholesterol and a polyethyleneglycol (PEG)-lipid at mole ratios of 50/10/38.5/1.5. DLin-MC3-DMA exhibits an optimized pK_a value that leads to dramatically enhanced potency^[1].