iCRT 14

677331-12-3

C21H17N3O2S

DMSO : >= 29 mg/mL (77.24 mM)

Stem Cell/Wnt

iCRT 14 is a novel potent inhibitor of beta-catenin-responsive transcription (CRT), with IC₅₀ of 40.3 nM against Wnt responsive STF16 luciferase. IC50 & Target: IC50: 40.3 nM (Wnt responsive STF16 luciferase)^[1] In Vitro: iCRT14 can interfere with TCF binding to DNA in addition to its ability to influence TCF-beta-cat interaction^[1]. iCRT14 (10, 25, 50 uM) effectively inhibits cell proliferation in BT-549 cells in a dose- and time-dependent manner, but still less potent than iCRT3^[2]. In Vivo: iCRT14 (50 mg/kg, i.p.) markedly decreases CycD1, proliferation of the tumors in HCT116 xenografts^[1].