Vergleich

Aloe emodin

ArtNr CS-3709-500mg
Hersteller ChemScene
Menge 500mg
Kategorie
Typ Molecules
Specific against other
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Similar products 481-72-1
Lieferbar
Alternative Names
Rhabarberone; 3-Hydroxymethylchrysazine
CAS
481-72-1
Purity
>98%
Formula
C15H10O5
MWt
270.24
Solubility
Ethanol : 1 mg/mL (3.70 mM; Need ultrasonic and warming); DMSO : 1 mg/mL (3.70 mM; Need ultrasonic)
Clinical Information
No Development Reported
Pathway
Autophagy
Target
Autophagy
Biological Activity
Aloe emodin is a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antitumor activity. IC50 value: Target: in vitro: aloe-emodin treatment led to the dissociation of heat shock protein 90 (HSP90) and ER alpha and increased ER alpha ubiquitination. Protein fractionation results suggest that aloe-emodin tended to induce cytosolic ER alpha degradation [1]. Aloe-emodin, a natural compound found in aloe, inhibited both proliferation and anchorage-independent growth of PC3 cells. Protein content analysis suggested that activation of the downstream substrates of mTORC2, Akt and PKCalpha, was inhibited by aloe-emodin treatment. Pull-down assay and in vitro kinase assay results indicated that aloe-emodin could bind with mTORC2 in cells and inhibit its kinase activity [2]. Of three anthraquinone derivatives, aloe-emodin, with a lower cytotoxicity showed concentration-dependently reducing virus-induced cytopathic effect and inhibiting replication of influenza A in MDCK cells. Galectin-3 also inhibited influenza A virus replication. Proteomic analysis of treated cells indicated galectin-3 up-regulation as one anti-influenza A virus action by aloe-emodin. Since galectin-3 exhibited cytokine-like regulatory actions via JAK/STAT pathways, aloe-emodin also restored NS1-inhibited STAT1-mediated antiviral responses in transfected cells: e.g., STAT1 phosphorylation of interferon (IFN) stimulation response element (ISRE)-driven promoter, RNA-dependent protein kinase (PKR) and 2'5', -oligoadenylate synthetase (2'5', -OAS) expression [3]. AE downregulated mRNA expression and promoter/gelatinolytic activity of Matrix Metalloproteinase (MMP)-2/9, as well as the RhoB expression at gene and protein level. AE suppressed the nuclear translocation and DNA binding of NF-kappaB [4]. in vivo: Aloe-emodin also exhibited tumor suppression effects in vivo in an athymic nude mouse model [2].

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Menge: 500mg
Lieferbar: In stock
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