ML204 (hydrochloride)

C15H19ClN2

H2O : >= 30 mg/mL (114.16 mM)

Membrane Transporter/Ion Channel; Neuronal Signaling

ML204 hydrochloride is a novel, potent, selective TRPC4 channel inhibitor with IC50 of 0.96 uM. exhibit 19-fold selectivity against TRPC6 channels in similar fluorescent assays. target: ML204 IC50: 0.96 uM In vitro: ML204 inhibited TRPC4beta-mediated intracellular Ca2+ rise. ML204 at 10 um showed >50% inhibition in only 7 of 68 binding assays for 68 GPCRs, ion channels, and transporters.[1] ML204 afforded good selectivity (19-fold) against TRPC6 channels and more modest selectivity against TRPC3 and TRPC5 (9-fold) channels. [2] In vivo: The selectivity of ML204 show no appreciable block by 10-20 um ML204 of TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and native voltage-gated sodium, potassium, and calcium channels in mouse dorsal root ganglion neurons.[1]