NSC23005 (sodium)

1796596-46-7

C13H16NNaO4S

DMSO : 6.4 mg/mL (20.96 mM; Need ultrasonic)

Others

NSC23005 sodium is a novel and effective p18 inhibitor (ED₅₀=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models. IC50 & Target: ED50: 5.21 nM (p18^INK4C)^[1] In Vitro: NSC23005 sodium is a novel class of INK4C (p18^INK4C or p18) small molecule inhibitor (p18SMIs), which is initially found by in silico 3D screening. NSC23005 sodium shows the most potent bioactivity in hematopoietic stem cells (HSCs) expansion (ED₅₀=5.21 nM). Notably, NSC23005 sodium does not show significant cytotoxicity toward 32D cells or HSCs, nor does it augment leukemia cell proliferation. NSC23005 sodium (ED₅₀=5.21 nM), shows no activity in promoting the proliferation of leukemia cells^[1]. In Vivo: NSC23005 sodium selectively promote HSCs division by inhibiting p18, thereby activating CDK4/6. NSC23005 sodium is a novel and effective p18 inhibitor in promoting HSCs expansion in both murine and human models^[1].