XMD16-5

1345098-78-3

C23H24N6O2

DMSO : >= 29 mg/mL (69.63 mM)

Metabolic Enzyme/Protease

XMD16-5 is a potent TNK2 inhibitor with IC₅₀ values of 16 and 77 nM for the D163E and R806Q mutations, respectively. IC50 & Target: IC50: 16 nM (TNK2, D163E mutation), 77 nM (TNK2, R806Q mutation)^[1] In Vitro: XMD16-5 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1, 000 nM). XMD16-5 has IC₅₀s of 16 nM and 77 nM for the D163E and R806Q mutations. The effects of XMD16-5 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD16-5^[1].