SCH 23390 (hydrochloride)

125941-87-9

C17H19Cl2NO

DMSO : >= 32 mg/mL (98.69 mM); H2O : < 0.1 mg/mL (insoluble)

GPCR/G Protein; Neuronal Signaling

SCH 23390 hydrochloride is a potent dopamine receptor D1 antagonist with K_i values of 0.2 and 0.3 nM for the D1 and D5. IC50 & Target: Ki: 0.2 nM (D1), 0.3 nM (D5)^[1] In Vitro: The commercially available hydrochloride salt has a molecular weight of 324.25 and is a white solid soluble in water (8 mg/mL), DMSO (3 mg/mL), or ethanol (2 mg/mL)^[1]. SCH 23390 also shows high affinity (K_i=9.3 nM) at h5-HT2C sites^[2]. SCH23390 blocks endogenous GIRK currents induced by either somatostatin or D3 dopamine receptors in AtT-20 cells (IC₅₀=268 nM)^[3]. In Vivo: SCH 23390 has been a major tool in gaining a better understanding of the role of the dopamine system. SCH 23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat^[1]. The repeated administration of SCH 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhances the steady-state density of dopamine D1 receptors in the striatum (+30%) and substantia nigra (+24%). This treatment also increases the production rates of dopamine D1 receptors in the striatum (+44%) and substantia nigra (+54%)^[4]. Systemic SCH 23390 reduces saccharin seeking evidenced by a significant reduction in active lever responding and a significant reduction in the number of active lever-contingent deliveries of the tone + light cue following pretreatment with 10 ug/kg SCH 23390^[5].