Trigonelline chloride

6138-41-6

C7H8ClNO2

DMSO : 6 mg/mL (34.56 mM; Need ultrasonic)

Others

Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. In Vitro: It is found that Trigonelline chloride (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline chloride attenuates H₂O₂ induced cell deaths and improves the antioxidant activity. In addition, Trigonelline chloride regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H₂O₂ induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirm that Trigonelline chloride significantly reduces the H₂O₂ induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline chloride concentration against H₂O₂ can induce the necrosis and apoptosis along with H₂O₂^[1]. In Vivo: Trigonelline chloride decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline chloride significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline chloride differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats^[2].