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Anti TAR DNA-Binding Protein 43 (TDP-43), phospho Ser410 pAb (Rabbit, Antiserum)

Anti TAR DNA-Binding Protein 43 (TDP-43), phospho Ser410 pAb (Rabbit, Antiserum)

ArtNr	CAC-TIP-PTD-P04
Hersteller	Cosmobio
Menge	100 ul
Kategorie	Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	TDP-43, phospho Ser410
Lieferbar
Manufacturer - Applications	ELISA, IHC(f), WB
Manufacturer - Category	Antibodies/Neurodegeneration/Primary Antibodies; Antibodies/Primary Antibodies/Neurodegeneration; Research Area/Cell Biology/Apoptosis/Primary Antibodies; Research Area/Cell Biology/Cell Cycle/Primary Antibodies; Research Area/Cell Biology/Cell Survival/Primary Antibodies; Research Area/Cell Biology/Gene Expression & Transcription/Primary Antibodies; Research Area/Cell Biology/Nuclear Import & Export/Primary Antibodies; Research Area/Cell Biology/Post Translational Modification & Processing/Primary Antibodies; Research Area/Cell Biology/Protein stability/Primary Antibodies; Research Area/Cell Biology/RNA biogenesis/Primary Antibodies; Research Area/Cell Biology/RNA Processing/Primary Antibodies; Research Area/Cell Biology/RNA Splicing/Primary Antibodies; Research Area/Cell Biology/RNA stability/Primary Antibodies; Research Area/Cell Biology/Viral transcription/Primary Antibodies; Research Area/Cell Types/Neurons/Primary Antibodies; Research Area/Development/Muscle/Primary Antibodies; Research Area/Disease/Alzheimer's Disease/Primary Antibodies; Research Area/Disease/Amyotrophic Lateral Sclerosis/Primary Antibodies; Research Area/Disease/Frontotemporal Dementia/Primary Antibodies; Research Area/Immunology & Inflammation/Virus/Primary Antibodies; Research Area/Neurobiology/Neurodegeneration/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Mitochondria/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Stress Granules/Primary Antibodies; Research Area/Systemic Physiology/Circadian Clock/Primary Antibodies
Maker	CAC
Short Description	Anti-TAR DNA-Binding Protein 43 (TDP-43), phospho Ser410 pAb was prepared from rabbits immunized with phospho-peptide [CMDSKSS(p)GWGM]. \\This pAb recognizes human TDP-43 phosphorylated on serine 410 and is validated for western blot, ELISA and IHC(f) analyses of TDP-43 proteinopathy.
Description	Anti-TAR DNA-Binding Protein 43 (TDP-43), phospho Ser410 pAb was prepared from rabbits immunized with phospho-peptide [CMDSKSS(p)GWGM]. This pAb recognizes human TDP-43 phosphorylated on serine 410 and is validated for western blot, ELISA and IHC(f) analyses of TDP-43 proteinopathy. TDP-43, a heterogeneous nuclear ribonucleoprotein, was identified as a component of ubiquitin-positive and tau-negative inclusions observed in cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Immunochemical analyses using antibodies generated against phospho- and non-phosphopeptides of human TDP-43 revealed that abnormally phosphorylated full-length TDP-43 (45 kDa), C-terminal fragments (~25 kDa) and smearing substances are deposited as intracellular inclusions in affected regions of FTLD-U and ALS cases. This antibody is a powerful tool for biochemical and immunohistochemical analyses of neurodegenerative diseases and for evaluation of cellular or animal models of TDP-43 proteinopathy. Specifications Product type primary antibody Immunogen CMDSKSS(p)GWGM, S(p): phosphoserine 410 Raised in rabbit Source serum Form liquid antiserum with 0.05% NaN3 as a preservative Volume 100 uL Label unlabeled Specificity phospho-TDP-43 Cross reactivity human Storage below -20° C and below -70° C for prolonged storage; aliquot to avoid freeze/thaw cycles. Recommended dilutions Western blotting: 1/1000-1/3000 Immunohistochemistry: 1/1000-1/5000 ELISA: 1/1000-1/5000 Other applications not tested Optimal dilutions/concentrations should be determined by end user References Hasegawa M, Arai T, Nonaka T, et al. Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Ann Neurol. 2008; 64(1):60– 70. doi:10.1002/ana.21425 ◢
Purification	Serum
Clonality	Polyclonal

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CAC-TIP-PTD-P04.pdf

CAC-TIP-PTD-P04-datasheet.pdf

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Menge: 100 ul

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