Rabbit anti-human Lys-63-specific deubiquitinase BRCC36 polyclonal Antibody

P46736

Non-conjugated

Metalloprotease that specifically cleaves \'Lys-63\'-linked polyubiquitin chains. Does not have activity toward \'Lys-48\'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes \'Lys-63\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes \'Lys-63\'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves \'Lys-63\'-linked ubiquitin in various substrates. Mediates the specific \'Lys-63\'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.

Liquid

Caprylic Acid Ammonium Sulfate Precipitation purified

Isolation and sequence of two genes associated with a CpG island 5\' of the factor VIII gene.Kenwrick S., Levinson B., Taylor S., Shapiro A., Gitschier J.Hum. Mol. Genet. 1:179-186(1992)