ITGA4 Antibody

Polyclonal Antibody

ITGA4

269C wild type antibody, Antigen CD49D, alpha 4 subunit of VLA 4 receptor antibody, CD49 antigen like family member D antibody, CD49 antigen-like family member D antibody, CD49d antibody, IA4 antibody, Integrin alpha 4 antibody, Integrin alpha 4 subunit antibody, Integrin alpha IV antibody, Integrin alpha-4 antibody, Integrin alpha-IV antibody, Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor) antibody, ITA4_HUMAN antibody, ITGA4 antibody, MGC90518 antibody, OTTHUMP00000205320 antibody, Very late activation protein 4 receptor, alpha 4 subunit antibody, VLA 4 subunit alpha antibody, VLA-4 subunit alpha antibody, VLA4 antibody

Recombinant Human Integrin alpha-4 protein (376-558AA)

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).

>95%, Protein G purified

Immunology

Recombinant Human Integrin alpha-4 protein (376-558AA)