Rabbit anti-human Disintegrin and metalloproteinase domain-containing protein 15 polyclonal Antibody,Biotin conjugated

Q13444

Biotin conjugated

Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.

Liquid

Caprylic Acid Ammonium Sulfate Precipitation purified

"Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence."Kraetzschmar J., Lum L., Blobel C.P. J. Biol. Chem. 271:4593-4596(1996)