TPH2 (Ab-19) Antibody

TPH2

MGC138871 antibody; ADHD7 antibody; FLJ37295 antibody; MGC138872 antibody; Neuronal tryptophan hydroxylase antibody; NTPH antibody; TPH 2 antibody; Tph2 antibody; TPH2_HUMAN antibody; Tryptophan 5-hydroxylase 2 antibody; Tryptophan 5-monooxygenase 2 antibody; Tryptophan hydroxylase 2 antibody

Synthesized non-phosphopeptide derived from human TPH2 around the phosphorylation site of serine 19 (G-FI-S(p)-L-D).

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Bader M., Science 299:76-76(2003).
Gibbs R.A., Nature 440:346-351(2006).
Pandey A., Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Neuroscience

Synthesized non-phosphopeptide derived from Human TPH2 around the phosphorylation site of serine 19 (G-FI-S(p)-L-D).