Hersteller |
Cusabio
|
Kategorie |
|
Typ |
Proteins |
Specific against |
other |
Menge |
1000ug |
Host |
E.coli |
ArtNr |
CSB-AP000061HU-1000 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Classification |
Hormone |
Subdivision |
Hormone |
Research Areas |
Signal Transduction |
Uniprot NO. |
P41159 |
Uniprot Entry Name |
LEP_HUMAN |
Gene Names |
LEP, OB, OBS |
Source |
E.Coli |
Expression Region |
22-167aa |
Sequence |
VPIQKVQDDT KTLIKTIVTR INDISHTQSV SS KQKVTGLD FIPGLHPILT LSKMDQTLAV YQQI LTSMPS RNVIQISNDL ENLRDLLHVL AFSKSC HLPW ASGLETLDSL GGVLEASGYS TEVVALSR LQ GSLQDMLWQL DLSPGC |
Protein Description |
Full Length of Mature Protein |
Tag Info |
Tag-Free |
Mol. Weight |
16.0 kDa |
Biological Activity |
Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human Leptin R transfected BaF3 murine proB cells is less than 2 ng/ml, corresponding to a specific activity of ? 5.0 x 105 IU/mg. |
Purity |
>97% as determined by SDS-PAGE and HPLC. |
Endotoxin |
Less than 1.0 EU/ug as determined by LAL method. |
Storage Buffer |
0.2 um filtered PBS, pH 7.4 , lyophilized |
Alias |
Obese protein, |
Relevance |
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. |
PubMed ID |
7984236; 7789654; 8626726; 7499240; 8621021; 15489334; 10428856; 9166907; 9144295; 9500540 |
Function |
Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways |
Involvement in disease |
Leptin deficiency (LEPD) |
Subcellular Location |
Secreted |
Protein Families |
Leptin family |
Tissue Specificity |
Adipose tissue is the main source of leptin it is also produced by other peripheral tissues such as the skeletal muscle (PubMed:7789654, PubMed:16052473, PubMed:12448771). Expressed by intercalated and striated tracts of submandibular and parotid salivary gland intralobular ducts (PubMed:12448771). Detected by fundic epithelium of the gastric mucosa (PubMed:10896907). Secreted into blood and gastric juice (PubMed:10896907). |
Paythway |
Jak-STATsignalingpathway |
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