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Recombinant Human Leptin protein(LEP) (Active)

Recombinant Human Leptin protein(LEP) (Active)

Manufacturer	Cusabio
Category	Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Peptides & Proteins Recombinant Proteins
Type	Proteins
Specific against	other
Amount	1000ug
Host	E.coli
Item no.	CSB-AP000061HU-1000
eClass 6.1	34160400
eClass 9.0	42020190
Available
Classification	Hormone
Subdivision	Hormone
Research Areas	Signal Transduction
Uniprot NO.	P41159
Uniprot Entry Name	LEP_HUMAN
Gene Names	LEP, OB, OBS
Source	E.Coli
Expression Region	22-167aa
Sequence	VPIQKVQDDT KTLIKTIVTR INDISHTQSV SS KQKVTGLD FIPGLHPILT LSKMDQTLAV YQQI LTSMPS RNVIQISNDL ENLRDLLHVL AFSKSC HLPW ASGLETLDSL GGVLEASGYS TEVVALSR LQ GSLQDMLWQL DLSPGC
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	16.0 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human Leptin R transfected BaF3 murine proB cells is less than 2 ng/ml, corresponding to a specific activity of ? 5.0 x 105 IU/mg.
Purity	>97% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Alias	Obese protein,
Relevance	May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
PubMed ID	7984236; 7789654; 8626726; 7499240; 8621021; 15489334; 10428856; 9166907; 9144295; 9500540
Function	Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways
Involvement in disease	Leptin deficiency (LEPD)
Subcellular Location	Secreted
Protein Families	Leptin family
Tissue Specificity	Adipose tissue is the main source of leptin it is also produced by other peripheral tissues such as the skeletal muscle (PubMed:7789654, PubMed:16052473, PubMed:12448771). Expressed by intercalated and striated tracts of submandibular and parotid salivary gland intralobular ducts (PubMed:12448771). Detected by fundic epithelium of the gastric mucosa (PubMed:10896907). Secreted into blood and gastric juice (PubMed:10896907).
Paythway	Jak-STATsignalingpathway

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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