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Recombinant Human Tumor necrosis factor receptor superfamily member 11A protein(TNFRSF11A) (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 11A protein(TNFRSF11A) (Active)

ArtNr	CSB-AP002321HU-250
Hersteller	Cusabio
Menge	250 ug
Quantity options	1 mg 100 ug 20 ug 250 ug 500 ug
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins By Organ Lymphatic System Cancer
Typ	Proteins Recombinant
Format	Solid
Specific against	other
Host	E.coli
Konjugat/Tag	Tag Free
Purity	>98% as determined by SDS-PAGE and HPLC.
Sequence	QIAPPCTSEK HYEHLGRCCN KCEPGKYMSS KC TTTSDSVC LPCGPDEYLD SWNEEDKCLL HKVC DTGKAL VAVVAGNSTT PRRCACTAGY HWSQDC ECCR RNTECAPGLG AQHPLQLNKD TVCKPCLA GY FSDAFSSTDK CRPWTNCTFL GKRVEHHGTE KSDAVCSSSL PARK
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Osteoclast differentiation factor receptor,Receptor activator of NF-KB,CD antigen CD265
Lieferbar
Manufacturer - Category	Cytokine / Tumor Necrosis Factor
Molecular Weight	19.1 kDa
Buffer	0.2 um filtered 20 mM Tris-HCl, pH 8.0, 150mM NaCl , lyophilized
General Research Areas	Cancer
Relevance	Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. {ECO:0000269\|PubMed:9878548}.
Expression Region	29-202aa
Function	Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
Subcellular Location	Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform RANK-e5a: Cell membrane, Single-pass type I membrane protein
Tissue Specificity	Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.
Involvement in disease	Familial expansile osteolysis (FEO); Paget disease of bone 2, early-onset (PDB2); Osteopetrosis, autosomal recessive 7 (OPTB7)
Pathway	NF-kappaBsignalingpathway
Gene Names	TNFRSF11A, RANK
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Biological activity	Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit sRANK Ligand induced nuclear factor kappa B(NFkappaB) in RAW 264.7 cells is less than 50 ng/ml, corresponding to a specific activity of ? 2.0 x 104 IU/mg in the presence of 15 ng/ml of recombinant sRANK Ligand.
Manufacturer - Format	Lyophilized powder
Uniprot Entry Name	TNR11_HUMAN
Protein Description	Partial
PubMed ID	9367155; 23664977; 9878548; 9774460; 15750601; 18669648; 10615125; 18606301

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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CSB-AP002321HU-250-datasheet.pdf

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Menge: 250 ug

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Lieferung vsl. bis 12.02.2026

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