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Recombinant Human Tumor necrosis factor receptor superfamily member 11A protein(TNFRSF11A) (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 11A protein(TNFRSF11A) (Active)

Item no.	CSB-AP002321HU-250
Manufacturer	Cusabio
Amount	250 ug
Quantity options	1 mg 100 ug 20 ug 250 ug 500 ug
Category	Oncology Neuroscience Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins By Organ Lymphatic System Cancer
Type	Proteins Recombinant
Format	Solid
Specific against	other
Host	E.coli
Conjugate/Tag	Tag Free
Purity	>98% as determined by SDS-PAGE and HPLC.
Sequence	QIAPPCTSEK HYEHLGRCCN KCEPGKYMSS KC TTTSDSVC LPCGPDEYLD SWNEEDKCLL HKVC DTGKAL VAVVAGNSTT PRRCACTAGY HWSQDC ECCR RNTECAPGLG AQHPLQLNKD TVCKPCLA GY FSDAFSSTDK CRPWTNCTFL GKRVEHHGTE KSDAVCSSSL PARK
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Osteoclast differentiation factor receptor,Receptor activator of NF-KB,CD antigen CD265
Available
Manufacturer - Category	Cytokine / Tumor Necrosis Factor
Molecular Weight	19.1 kDa
Buffer	0.2 um filtered 20 mM Tris-HCl, pH 8.0, 150mM NaCl , lyophilized
General Research Areas	Cancer
Relevance	Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. {ECO:0000269\|PubMed:9878548}.
Expression Region	29-202aa
Function	Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
Subcellular Location	Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform RANK-e5a: Cell membrane, Single-pass type I membrane protein
Tissue Specificity	Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.
Involvement in disease	Familial expansile osteolysis (FEO); Paget disease of bone 2, early-onset (PDB2); Osteopetrosis, autosomal recessive 7 (OPTB7)
Pathway	NF-kappaBsignalingpathway
Gene Names	TNFRSF11A, RANK
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Biological activity	Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit sRANK Ligand induced nuclear factor kappa B(NFkappaB) in RAW 264.7 cells is less than 50 ng/ml, corresponding to a specific activity of ? 2.0 x 104 IU/mg in the presence of 15 ng/ml of recombinant sRANK Ligand.
Manufacturer - Format	Lyophilized powder
Uniprot Entry Name	TNR11_HUMAN
Protein Description	Partial
PubMed ID	9367155; 23664977; 9878548; 9774460; 15750601; 18669648; 10615125; 18606301

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 ug

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Delivery expected until 2/12/2026

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