Hersteller |
Cusabio
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Menge |
10ug |
Host |
E.coli |
ArtNr |
CSB-EP023317HU-10 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Research areas |
Signal Transduction |
Target / Protein |
TCN1 |
Biologically active |
Not Test |
Expression system |
E.coli |
Species of origin |
Homo sapiens (Human) |
Uniprot ID |
P20061 |
AA Sequence |
EICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVV LSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSG ELALIILALGVCRNAEENLIYDYHLIDKLENKFQA EIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYST AEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCV KKSLINGQIKADEGSLKNISIYTKSLVEKILSEKK ENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQT LNTVLTEISQGAFSNPNAAAQVLPALMGKTFLDIN KDSSCVSASGNFNISADEPITVTPPDSQSYISVNY SVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIF GFTMEERSWGPYITCIQGLCANNNDRTYWELLSGG EPLSQGAGSYVVRNGENLEVRWSKY |
Tag Info |
N-terminal 6xHis-SUMO-tagged |
Expression Region |
24-433aa |
Protein length |
Full Length of Mature Protein |
MW |
61.6 kDa |
Alternative Name(s) |
Haptocorrin Short name: HC Protein R Transcobalamin I Short name: TC I Short name: TCI |
Relevance |
Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach. |
References |
"Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin."Furger E., Frei D.C., Schibli R., Fischer E., Prota A.E.J. Biol. Chem. 288:25466-25476(2013) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach. |
Subcellular Location |
Secreted |
Protein Families |
Eukaryotic cobalamin transport proteins family |
Tissue Specificity |
Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils. |
Tag Information |
N-terminal 6xHis-SUMO-tagged |
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