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Active CASP3 Monoclonal Antibody

Active CASP3 Monoclonal Antibody

ArtNr	E-AB-22115-120
Hersteller	Elabscience
Menge	120 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot Immunofluorescence Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB, IF, IHC-P
Clon	5A2
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	https://www.sciencedirect.com/science/article/pii/S2162253122003006 https://www.mdpi.com/1806946 https://pubs.rsc.org/en/content/articlelanding/2021/fo/d1fo01547h https://www.sciencedirect.com/science/article/pii/S1382668920300880 https://www.sciencedirect.com/science/article/pii/S0161813X18304170 https://www.spandidos-publications.com/10.3892/ol.2018.9635?text=abstract https://link.springer.com/article/10.1134/S0022093021060120
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	A830040C14Rik, Apopain, CASP-3, CASP3, CASP3, Casp3a, Caspase 3, Caspase 3, apoptosis-related cysteine peptidase, Caspase 3, apoptosis-related cysteine protease, Caspase 3, apoptosis-related cysteine protease a, Caspase-3 subunit p12, CC3, CPP-32, CPP32, CPP32B, Cysteine protease CPP32, EC 3.4.22.56, LICE, mldy, OTTHUMP00000165052, OTTHUMP00000165053, OTTHUMP00000165054, PARP cleavage protease, Procaspase3, Protein Yama, SCA 1, SCA-1, SREBP cleavage activity 1, Yama
Similar products	CASP3, CPP32, Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1, Caspase-3 subunit p12, CC3, LICE, CASP-3, CPP-32, SCA-1, Caspase 3, apoptosis-related cysteine protease, CPP32B, PARP cleavage protease, Yama, A830040C14Rik, mldy, SCA 1, OTTHUMP00000165054, Procaspase3, Casp3a, apoptosis-related cysteine peptidase, apoptosis-related cysteine protease a, EC 3.4.22.56, OTTHUMP00000165052, OTTHUMP00000165053
Versandbedingung	Gekühlt
Gefahren-Info	Comply with cargo safety certificate
Lieferbar
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	Active Caspase-3
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Observed Molecular Weight	17kDa
Manufacturer - Research Areas	Cancer, Cell Biology, Metabolism, Neuroscience
Background	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
Concentration	1 mg/mL
Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Purification Method	Protein A purification
Recommended Dilution	WB 1:500-1:1000; IHC 1:100-1:200; IF 1:100-1:200
Abbreviation	Active Caspase-3
Clonality	Monoclonal
Immunogen	Recombinant Protein
Category ID III	Monoclonal Antibodies

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